Abstract
Oxidative/antioxidant balance and matrix metalloproteinases level in the knee cartilage of rats under experimental osteoarthritis and probiotic administration
Highlights
Osteoarthritis (OA) occupies an important place among the diseases of the joints
The progression of inflammation in the joints is intensified by free radical processes, that lead to damage of synovial cells, destruction of cartilage, erosion of bones, and joint surfaces [11, 12]
We found the effect of multistrain PB on the system disruption of free radical processes and levels of matrix metalloproteinases (MMPs) in the bloodstream during experimental OA [15, 16], the local biochemical mechanisms of these processes were not shown in the cartilage yet
Summary
Osteoarthritis (OA) occupies an important place among the diseases of the joints. OA develops in 90% of the population over 65 years old, in some of them it leads to the development of disability. The state of the microbiome is closely related to the pathogenesis of some metabolic and inflammatory diseases, that may involve in the development of OA. Factors such as stress, use of medication such as nonsteroidal anti-inflammatory drugs may lead to the formation of oxidative stress in intestines and have been found to contribute to intestinal dysbiosis [7]. We found the effect of multistrain PB on the system disruption of free radical processes and levels of MMPs in the bloodstream during experimental OA [15, 16], the local biochemical mechanisms of these processes were not shown in the cartilage yet. The aim of this study to investigate the effect of a multistrain live probiotic on the oxidative-antioxidant balance and activity of MMPs in the cartilage of rats under conditions of experimental osteoarthritis
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