Abstract
Background Multiple sclerosis (MS) is an autoimmune disease of central nervous system, which unknown etiology, but recent studies suggest important role of oxidative stress in its pathogenesis. The aim of our study was to analyze various markers of oxidative and nitrative damage, their mutual correlations and correlations with the state of the bloodbrain barrier (BBB) in multiple sclerosis patients. We also monitored the level of uric acid, an antioxidant.
Highlights
Multiple sclerosis (MS) is an autoimmune disease of central nervous system, which unknown etiology, but recent studies suggest important role of oxidative stress in its pathogenesis
We monitored the level of uric acid, an antioxidant
The function of bloodbrain barrier (BBB) in tested group was evaluated using the QA index that indicated its damage in 7 males and 3 females
Summary
The aim of our study was to analyze various markers of oxidative and nitrative damage, their mutual correlations and correlations with the state of the bloodbrain barrier (BBB) in multiple sclerosis patients
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