Abstract
The modulation of oxygen-radical mediated oxidation of amino acids in proteins underlies a general mechanism for regulating the turnover of one enzyme with respect to another. The accumulation of altered enzyme forms which occurs during ageing and in some premature ageing diseases may reflect shifts in the balance between the rate of protein oxidation on the one hand, and the rate of degradation of oxidized protein on the other. The oxidation of key enzymes may also be involved in the bactericidal action of neutrophils and in the autodestruction of neutrophils following periods of respiratory burst. In defining the molecular basis of oxygen toxicity, the oxidative inactivation of key enzymes must be taken into account, along with lipid peroxidation and DNA strand scission.
Published Version
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