Abstract
AbstractThe copper(II) complex of 2‐quinoxalinol salen (salqu) is an efficient catalyst for the selective oxidation of propargylic alcohols to yield the corresponding α,β‐acetylenic carbonyl compounds when used in combination with the oxidant tert‐butyl hydroperoxide (TBHP). Excellent yields (up to 99 %) are achieved for a variety of propargylic alcohols within 1 h of reaction time. The (salqu)copper(II) complex with TBHP can be used with propargylic alcohols that contain alkyl groups in the α‐position, which can be difficult to oxidize selectively with other commonly available methods. By using this catalytic protocol, excellent selectivity was also achieved for the oxidation of propargylic alcohols over that of isolated hydroxy groups, triple bonds, or propargylic methylene groups.
Published Version
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