Abstract

The oxidation of alcohols constitutes the synthetically most important application of chromium(VI) oxidation. The matter has been largely divided into 4 sections: The first section includes acid catalysed oxidations with chromium trioxide and chromic acid in a variety of solvents including water, acetic acid, acetone (Jones’ reagent), dimethylsulphoxide, and dimethylformamide. A second section deals with oxidations promoted by a family of chromium(VI) reagents obtained from chromium trioxide, chromic acid, and halochromic acids with heterocyclic bases. Important members of this class are the chromium trioxide-(pyridine)2 complex (Sarett’s reagent) and the pyridinium chlorochromate introduced by E. J. Corey. The third section describes oxidations carried out under neutral or almost neutral conditions. It includes oxidations with di-tert-butyl chromate, chromium trioxide in hexamethylphosphoramide, and with tetrabutylammonium salts of chromic acid under various conditions. A fourth section deals with the recently introduced chromium(VI) reagents supported on various insoluble organic and inorganic matrices. Two smaller sections, which briefly discuss the mechanism of oxidation of alcohols with chromium(VI) and the influence of structure and stereochemistry of the alcohol on the oxidation rate complete the chapter.

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