Abstract
The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome. The 2-oxo-1,3-oxazolidine ring is a cyclic carbamate skeleton quite rare in natural product chemistry but very popular in the Synthetic Organic Chemistry since the Evans' report (1) in 1981 on the use of enantiomerically pure 4- substituted oxazolidin-2-ones as chiral auxiliaries in asymmetric synthesis. Oxazolidinones have also a large application as protective groups for the 1,2-aminoalcohol system. Finally, the introduction in the pharmaceutical market of Linezolid (2), an oxazolidin-2-one-based antibacterial drug, attracted the interest of the scientists and resulted in the production of several publications.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
