Abstract
Penile cancer is a rare pathology. For penile cancer surgical treatment, radiotherapy, chemotherapy, and combined modality treatment are available. Because of great importance of this organ for mental condition of patient, the development of organ-preserving methods allowing to minimize impact on patient's quality of life without compromising of oncological results is desirable. In the Center of Laser and Photodynamic diagnosis and treatment of tumors in P.A. Herzen Moscow Cancer Research Institute the methods of photodynamic therapy in patients with penile cancer have been developed. From 2011 to 2013 the treatment was conducted in 11 patients with precancer and cancer of penile. The average age was 56.6. According to morphological diagnosis photodynamic therapy (PDT) was performed using two methods. One method included topical application of agent for PDT and the second intravenous administration of photosensitizer. For topical application alasens was used and for intravenous injection we applied radachlorine. All patients had no complications. Complete regression was achieved in 9 patients, and partial regression in 2. Thus, the results showed that photodynamic therapy for penile cancer stage Tis-1N0M0 permits performing organ-preserving treatment with satisfactory oncological results and no impairment of patient's quality of life.
Highlights
Penile cancer is a rare pathology [1]
The results showed that photodynamic therapy for penile cancer stage Tis-1N0M0 permits performing organ-preserving treatment with satisfactory oncological results and no impairment of patient’s quality of life
Total penectomy is preferred for ≥T2 tumors, some T2 tumors are amenable to partial penectomy based on location
Summary
Penile cancer is a rare pathology [1]. In 2012 in Russia 493 new cases were registered [2]. For penile cancer surgical treatment, radiotherapy, chemotherapy, and combined modality treatment are available. Amputation at the level of pubic symphysis with perineal urethrostomy, emasculation, degloving, and Ducuing surgery for regional lymph node metastases. Penile-sparing surgical modalities including Mohs’ micrographic surgery and laser ablation are considered for small tumors, if located on the glans and margins ≥3 mm can be attained [5]. Radiotherapy is used as option of organ-preserving treatment. Because of great importance of this organ for mental condition of patient, the development of organpreserving methods allowing to minimize impact on patient’s quality of life without compromising of oncological results is desirable. Penile preservation is superior in functional and cosmetic outcomes and should be offered as a primary treatment modality in men with low stage penile cancer [6]
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