Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma.

Zhishuang Li,Aifeng Pan,Xiaojuan Wu,Li Li,Jingjing Cui,Ming Jia

doi:10.1186/s13000-015-0401-2

Zhishuang Li, Aifeng Pan + Show 4 more

Open Access

https://doi.org/10.1186/s13000-015-0401-2

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Journal: Diagnostic pathology	Publication Date: Sep 17, 2015
Citations: 47	License type: CC BY 4.0

Affiliation: Shandong University

Abstract

BackgroundTrichorhinophalangeal syndrome 1 (Trps1) gene is a member of GATA transcription factor family and has an important function in tumorigenesis and progression. However, there are rare studies on its roles in carcinogenesis and prognostic significance in human osteosarcoma.MethodsThe expression of Trps1 was detected by immunohistochemistry, and MVD was evaluated to determine the amounts of microvessels by counting CD31-positive endothelial cells.ResultsOf the 74 cases that underwent study, Trps1-positive cases were 24. And it was associated with MVD significantly (P = 0.008). The data also exhibited more cases of remote metastasis (P = 0.013) and higher Enneking stage (P = 0.017) in Trps1-positive group compared to Trps1-negative group. Univariate analysis revealed that distant metastasis, MVD and Trps1 expression were associated with a lower 3-year overall survival rate and disease-free survival rate (P = 0.003, and P = 0.012 respectively). Furthermore, Trps1 and distant metastasis retained their significant prognostic effects on patients survival rate by multivariate analysis (P < 0.05).ConclusionsTrps1 plays a crucial role in osteosarcoma angiogenesis, metastasis and clinical surgical stage. Trps1 can be a novel promising prognostic marker and therapeutic target, and antiangiogenic therapy which targets Trps1 molecule in patients with osteosarcoma may lead to improved prognosis and longer-term survival.

Highlights

Trichorhinophalangeal syndrome 1 (Trps1) gene is a member of GATA transcription factor family and has an important function in tumorigenesis and progression
In order to evaluate the relationship between Trps1 and angiogenesis, microvessels were stained by CD31
Univariate analysis revealed that distant metastasis, Microvessels Density (MVD) and Trps1 expression were associated with a poorer 3-year overall and disease-free survival rate (P < 0.05) but were not associated with gender, age, tumor position, size, histological type and differentiation (P > 0.05)

Summary

Introduction

Trichorhinophalangeal syndrome 1 (Trps1) gene is a member of GATA transcription factor family and has an important function in tumorigenesis and progression. There are rare studies on its roles in carcinogenesis and prognostic significance in human osteosarcoma. Osteosarcoma is the most common primary malignant bone tumors occurring in adolescents and young adults [1,2,3]. Various treatments such as wide excision surgery of tumors, radiotherapy, chemotherapy as well as neoadjuvant chemotherapy have made significant improvements in the long-term outcome of these patients [4, 5], it is still not satisfactory. Presence of primary metastasis has been proved to be an independent prognostic indicator in osteosarcoma [7].

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