Abstract
ATP-gated P2X3 receptors play a crucial role in neurogenic inflammation and neuronal sensitization, which might is associated with pain. Our study was to investigate whether P2X3 receptors are involved in tooth pain. Dental pulp tissues were obtained from normal (n=14) and painful (n=16) pulps in permanent teeth as well as normal (n=10) and painful (n=14) pulps in primary teeth. Western blot and Real-time fluorescence quantitative PCR were used to detect the expression level of P2X3 receptors in dental pulp tissues. The results showed that P2X3 receptors were upregulated significantly in painful pulp when compared with normal pulp in primary teeth (P<0.05). However, there was no difference of the expression of P2X3 receptors between normal and painful permanent tooth pulp (P>0.05). Interestingly, we found that the intraneural expression of P2X3 receptors of primary tooth pulp was significantly higher than that of permanent tooth pulp (P<0.05). Our study shows for the first time that the P2X3 receptors may be related to primary dental pain, but not to permanent dental pain
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