Abstract
Yolk sac tumors (endodermal sinus tumors) are an important subgroup of germ cell tumors of the ovary. They are seen in young females and are highly aggressive, but respond well to treatment. Although different morphological patterns can be seen on light microscopy, granulomatous reaction and giant cells are a very rare occurrence. We report the case of a young female with ovarian yolk-sac tumor in which a widespread granulomatous reaction was seen, causing a diagnostic dilemma.
Highlights
Ovarian yolk sac tumors (YST) are malignant germ cell tumors and are most common in children and young females
We report a case of yolk sac tumor with extensive granulomatous reaction showing numerous giant cells of Langhans type and tumor giant cells
Varied architectural patterns can be identified on light microscopy in yolk sac tumours (YST)
Summary
Ovarian yolk sac tumors (YST) are malignant germ cell tumors and are most common in children and young females. The presence of giant cells and granulomatous reaction has not been described in YST except for a rare association with syncytiotrophoblastic giant cells [1]. We report a case of yolk sac tumor with extensive granulomatous reaction showing numerous giant cells of Langhans type and tumor giant cells. Ultrasound examination of the abdomen showed a mass, arising from right adnexa, 15 cms in diameter, with heterogenous echotexture and central necrosis.
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