Abstract
ABSTRACT The excretion of 17-hydroxycorticosteroids, total and fractional 17-ketosteroids, pregnanetriol, pregnanediol and testosterone were determined in the urine of a 34-yr-old Negro woman with virilization caused by an ovarian lipoid cell tumor. Urinary levels of 17-ketosteroids (17-KS), androsterone (A) and etiocholanolone (E) were significantly elevated, were not suppressed by dexamethasone, but were augmented by metyrapone, presumably through increased ACTH secretion. Human chorionic gonadotropin (HCG) administration also resulted in a marked increase in 17-KS. Basal levels of pregnanetriol and testosterone glucuronide, significantly above normal, were further elevated by HCG and metyrapone. These findings are interpreted to indicate that the tumor secreted 17-hydroxyprogesterone and an androgen which may have been androstenedione, testosterone or both. 11-Hydroxylase function characteristic of adrenal steroid synthesis was not proved for the tumor, but the increased excretion of pregnanetriol and ...
Published Version
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