Abstract
Forty-six patients with ovarian cancer were treated at St. Jude Children's Research Hospital (SJCRH) from 1963 to 1988. The mean age of the patients was 10.8 years (range 22 months-17 years), and the majority of the neoplasms were germ cell tumors (n = 43). Using the FIGO classification, 18 patients had stage I disease, four had stage II, 15 stage III, and 9 patients had stage IV disease. The overall survival rate was 69.6%. The age at the time of diagnosis did not seem to affect outcome. All patients with stage I disease survived, regardless of the type of neoplasm or the treatment modalities employed. For more advanced disease, survival rates were 50–60% for stages II and III, and only 11% for stage IV. The type of neoplasm also affected survival rates. Survival rates of 90–100% were recorded in patients with dysgerminomas and with mixed germ cell tumors, and the overall survival rates in patients with immature teratomas and endodermal sinus tumors were 64% and 50%, respectively. The series demonstrates the importance of early diagnosis of ovarian germ cell tumors.
Published Version
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