OUTCOMES OF COVID-19 IN EGYPTIAN PATIENTS

Abstract

Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2), is an ongoing pandemic that has already affected millions of patients worldwide, and is associated with significant morbidity and mortality burden. Objective: To characterize the clinical manifestations and outcomes of COVID-19 in Egyptian patients. Patients and Methods: This was a retrospective cohort study conducted on 333 subjects with COVID-19 who were admitted to Al-Azhar University Specialized Hospital, Quarantine Hospital, and some patients during follow up after discharge from other quarantine hospitals, during the period from 15th of April, 2020 to 31st of August, 2020. Presenting clinical manifestations, laboratory findings, imaging findings and mortality rate were recorded from electronic medical records and sometimes from patients. Results: The vast majority had cough (82.6%) and fever (51.7%), while 23.4% had dyspnea among COVID-19 patients. There was a significant older age among died cases (66.4 ± 17.4 years old) than recovered cases (40.3 ± 14.9 years old) (p- value <0.001). The overall co-morbiditis 89.5% and 38.5% in died and recovered cases respectively. Significant differences (p-value < 0.001) were found between died and recovered patients regarding, Lymphocytes and neutrophilic/ lymphocytic ratio (NLR). The C-reactive protein (CRP), ferritin and D-Dimer were higher in died cases. Crazy paving appearance was the findings in CT chest in deceased patients. The mortality rate was 5.7%. Conclusions: Age, obesity, lymphopenia, D. dimer, CT chest findings and other co-morbid disease could be considered as a predictor of outcome among COVID-19 patients.