Abstract
An outbreak of hand, foot, and mouth disease (HFMD) that occurred in a Juku in Fengtai District, Beijing, China, in 2015 was monitored by the China Information System for Disease Control and Prevention. Epidemiological investigation showed that 11 cases occurred from two classes in the preschool art training department in the Juku. Coxsackievirus A6 (CV-A6) was identified as the causative pathogen of the outbreak via sequences analysis of products of real-time reverse-transcription polymerase chain reaction (RT-PCR) and nested RT-PCR. Phylogenetic analysis showed that CV-A6 strains isolated in this study clustered with epidemic strains isolated in China since 2013. The outbreak ended quickly with effective measures. This event indicates that continuous surveillance of HFMD etiological agents other than enterovirus 71 and coxsackievirus A16 is necessary.
Highlights
Hand, foot, and mouth disease (HFMD) is characterized by mild febrile illness and vesicular exanthema on hands, feet and mouth
Study design An HFMD outbreak associated with Coxsacki‐ evirus A6 (CV-A6) in a Juku in Fengtai District, Beijing, China was monitored by the China Information System for Disease Control and Prevention, From July 17–22
From July 17–22, 11 cases in the Juku were reported by different hospitals to the China Information System for Disease Control and Prevention
Summary
Foot, and mouth disease (HFMD) is characterized by mild febrile illness and vesicular exanthema on hands, feet and mouth. HFMD is a virus-induced infectious disease affecting mainly infants and children, typically causing outbreaks in kindergartens and primary schools. The predominant causative agents of HFMD are enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16); other CVA, CVB, and some echoviruses have been reported to cause HFMD (He et al 2013). Since 2012, a newly emerged enterovirus (CV-A6) has rapidly replaced the original circulating strains EV-A71 and CV-A16, becoming the predominant etiological agent of HFMD in some areas in China (Han et al 2014; Lu et al 2014). CV-A6 is classified as human enterovirus A in the family Picornaviridae, genus Enterovirus, and is an etiological agent of mild herpangina or HFMD (Mirand et al 2012; Osterback et al 2009; Sinclair et al 2014; Wei et al 2011). CV-A6 has been reported to cause outbreaks worldwide (Feder et al 2014; Puenpa et al 2013; Fujimoto et al 2012; He et al 2013)
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