Abstract
In the Russian Federation, up to half a million patients suffering from burns are registered each year. Of these, around one in ten have deep lesions; in one in seven or eight, the burns cover an area, exceeding 20% of the body surface. Mortality for deep burns is about 15% with no tendency to decrease [1].
Highlights
In the Russian Federation, up to half a million patients suffering from burns are registered each year
The fastest wound healing time, 44 days, was found in the group treated with necrectomy followed by the administration of Adipose Tissue Mesenchymal Stem Cells (ATMSCs), supplemented with the application of wound dressings based on chitosan-copolyamide
A microbiological study of wound discharge on day 7 found the minimum level of microorganism vegetation in the group of animals treated with necrectomy, ATMSCs, and wound dressings based on chitosan-copolyamide (Table 4)
Summary
The combined use of wounds dressings of nanofibers chitosan and copolyamide with MSC accelerates the regeneration process by 26% (p < 0.05), with the introduction of AMSCs accelerating the development of granulation tissue by the fifth day of observation by 83% (p < 0.01). Joint use of wound coverings on the basis of hyaluronic acid with AMSCs is accompanied by an increase in the number of vessels of the microcirculatory bed in the defect area by 185% (p < 0.01). Clinical evaluation of the effectiveness of drugs with stem cells - a gel for topical application and a suspension of MSC LC for injection administration demonstrate their ability to optimize regeneration in the burn zone.
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