Osteosarcoma’s STAT-3 Vrs Kaempferia parviflora’s Compounds : Possible Drug Candidates

Abstract

Osteosarcoma is a dominant type of bone cancer, associated with osteophytes (bone cells). Afflicts all age groups; generally manifesting in long bones of human physiology(also other parts; including fine joints). Chemotherapy, surgery and radiation are the current therapeutics – with uncertain results; often associated with high degree of failure; swift relapse; rebound aggression and above all with debilitating post treatment out come conditions. In this investigation in silico drug designing procedures have been used to predict natural compounds from Kaempferia parviflora (black ginger) as possible drug candidates for osteosarcoma. 8 of its phyto-compounds (PCs) are found to be non-toxic and also pass the Lipinski’s rule of 5 (@ 100%) vis-à-vis the over expressed Signal Transducer And Activator Of Transcription 3(STAT3) protein of the dreaded osteosarcoma. All the 8 PCs indicate better binding affinity (greater likeness) than the current best popular allopathic drug Zoledronic acid (Toxic). All the 8 offer good-excellent likeness. Alpha- Copaene (non Toxic) emerges as the Champion.