Osteosarcoma with metastatic disease at presentation, surgical management: two cases report

Abstract

Osteosarcoma is the most common primary sarcoma of bone, most of them occurring in adolescents. Around 15% and 30% of patients with malignant bone tumors present with metastatic disease at the time of diagnosis. There is limited evidence on the best therapeutic strategy in these patients. We report two cases of osteosarcoma of the proximal femur in patients with metastatic disease at diagnosis, who were treated surgically and evaluated their evolution throughout follow-up and review the main literature on this complex disease.