Abstract
Osteoporosis is a common skeletal disorder that occurs as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building. Bone resorption inhibitors, e.g., bisphosphonates, have been designed to treat osteoporosis. Teriparatide, an anabolic agent, stimulates bone formation and corrects the characteristic changes in the trabecular microarchitecture. However, these drugs are associated with significant side effects. It is therefore crucial that we continue to research the pathogenesis of osteoporosis and seek novel modes of therapy. This editorial summarizes and discusses the themes of the six articles published in our Special Issue “Osteoporosis: From Molecular Mechanisms to Therapies 3.0”, a continuation of our 2020 Special Issue "Osteoporosis: From Molecular Mechanisms to Therapies". These Special Issues detail important global scientific findings that contribute to our current understanding of osteoporosis.
Highlights
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All of the articles submitted to us for this Special Issue, “Osteoporosis: From Molecular Mechanisms to Therapies 3.0”, underwent a rigorous peer review process, and six met our inclusion criteria. Four of these articles detail original research into (i) a novel molecular mechanism that represses high-fat diet-mediated osteoporosis and body adiposis, (ii) evidence favoring the targeting of visfatin in the treatment of metastatic chondrosarcoma, (iii) a potential role for the bioactive compound paeonoside in the treatment of osteoporosis, and (iv) the use of a novel mutant RANKL that can effectively treat RANKLinduced osteoclastogenesis in both the cellular and preclinical modeling of osteoporosis, apparently without the toxicity that commonly accompanies other antiosteoporotic drugs
This Special Issue contains two reviews, the first of which discusses the potential therapeutic benefits of using melatonin in the treatment of osteoporosis and osteolytic bone metastasis, while the second describes in vitro and in vivo evidence for the microRNA regulation of the bone/fat formation switch in bone marrow, which has important implications for the homeostasis of bone marrow
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Osteoporosis: From Molecular Mechanisms to Therapies 3.0.
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