Abstract
Osteoporosis is a common skeletal disorder, occurring as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building. Bone resorption inhibitors, e.g., bisphosphonates, have been designed to treat osteoporosis, while anabolic agents such as teriparatide stimulate bone formation and correct the characteristic changes in the trabecular microarchitecture. However, all of these drugs are associated with significant side effects. It is therefore crucial that we continue to research the pathogenesis of osteoporosis and seek novel modes of therapy. This editorial summarizes and discusses the themes of the fifteen articles published in the Special Issue, Osteoporosis: From Molecular Mechanisms to Therapies 2019, as part of the global picture of the current understanding of osteoporosis.
Highlights
Osteoporosis is a common skeletal disorder, occurring as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building
It is crucial that we continue to research the pathogenesis of osteoporosis and seek novel modes of therapy
After undergoing rigorous peer review, 15 were deemed appropriate for inclusion in this issue. They can be broadly organized into two main categories: (i) The molecular mechanisms of osteoporosis, and (ii) novel strategies in the treatment of osteoporosis, both of which are discussed below
Summary
Osteoporosis is a common skeletal disorder, occurring as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building. E.g., bisphosphonates, have been designed to treat osteoporosis, while anabolic agents such as teriparatide stimulate bone formation and correct the characteristic changes in the trabecular microarchitecture. In response to the call for papers for this special issue “Osteoporosis: From Molecular Mechanisms to Therapies 2019”, we received many research articles from all over the world.
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