Abstract
AbstractIntroduction: Lactoferrin (Lf) is a protein in the transfer-rin family with many biological functions. One novel activity of lactoferrin described recently is its regulatory function in bone morphogenesis. Lactoferrin has been shown to promote the growth, development, and differentiation of osteoblasts as well as to decrease osteoclast survival. Lactoferrin receptors (LfRs) mediate the multiple functions of lactoferrin. This review focuses on LfRs associated with bone and the intestines. The best known LfR is small intestine LfR (intelectin), which facilitates iron absorption and iron metabolism in humans. Many data fromin vitroandin vivostudies have indicated that lactoferrin promotes bone formation by increasing the proliferation of osteoblasts and the ability of cells to synthesize and mineralize the bone matrix. Lactoferrin additionally inhibits osteoclastogenesis, reducing the number of osteoclasts and thus bone resorption. Lactoferrin, with its numerous antimicrobial, anti-inflammatory, and also osteogenic properties has found a number of applications in contemporary dentistry, especially in dental surgery, in periodontology, and in pedodontics.Summary: This review presents andin vivo in vitrostudies demonstrating the osteogenic and anti-inflammatory activity of Lf and its practical application in oral surgery and dentistry.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
