Abstract
Preface 1. Molecular regulation of wound healing - Introduction - The immediate response - Inflammatory response - Reepithelialization - Granulation tissue formation - Wound contraction - Angiogenesis - Remodeling - Resolution of inflammation - Proteases in wound healing - Anti-microbial peptides - Chronic wound healing - References 2. Role of hyaluronan in wound healing - Introduction - Structure - Biosynthesis - Mammalian hyaluronidase - Hyaluronan fragment - Role on cancer - Hyaluronan in dermis and epidermis - Role on wound healing - References 3. Lactoferrin structure, function and genetics - Introduction - Lactoferrin expression and localization - Lactoferrin structure - Iron-binding properties of lactoferrin - Lactoferrin metabolism - Anti-bacterial activity of lactoferrin - Bactericidal activity of lactoferrin derived peptides - Anti-viral activity of lactoferrin - Anti-parasitic and anti-fungal activity of lactoferrin - Immunoregulatory properties of lactoferrin - Anti-inflammatory activity of lactoferrin - Anti-oxidative effect of lactoferrin - Genetics - Other functions - References 4. Lactoferrin as a signaling mediator - Introduction - Intestinal lactoferrin receptor (Intelectin) - LDL receptor related protein (LRP) - Hepatocyte lactoferrin receptor - Nucleolin - Monocytes and macrophage lactoferrin receptor - Dendritic cell lactoferrin receptor - Lymphocyte lactoferrin receptor - Cell cycle control and apoptosis induction - Angiogenesis - Fibroblasts - Osteogenic differentiation - Osteoclasts - Chondrogenic differentiation - Adipogenesis - Lactoferrin receptor in brain capillary endothelial cells - Platelet lactoferrin receptor - Lactoferrin receptor in epithelial cells - Lactoferrin receptor in respiratory epithelial cells - Transcription regulator - References 5. Effects of lactoferrin on skin wound healing - Introduction - Cell proliferation and migration - Collagen gel contraction by fibroblasts - Molecular mechanism of wound healing - Regulation of cell adhesion - Hyaluronan synthesis - Production of extracellular matrix components - Corneal epithelia wound healing - Talactoferrin - Cutaneous immunity - Anti-apoptotic effect - Diabetic ulcers - References
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