Abstract
Bone defects have recently become one of the biggest problems for surgeons. This study aims to compression osteogenic properties of cerium and gallium doping in mesoporous bioactive glass-ceramics (MBGCs). MBGCs are synthesized using sol-gel method through evaporation induced self-assembly technique. Small-angle X-ray scattering (SAXS) revealed size of nanoparticle in MBGCs is ∼29 nm. The impact of cerium and gallium ions on ceramics was characterized using Fourier transform infrared (FTIR) and 29Si Magic angle spinning nuclear magnetic resonance (MAS-NMR) spectroscopic methods. Images of samples taken with a transmission electron microscope show aggregated particles with irregular forms. MBGCs doped with cerium and gallium in vitro biocompatibility investigations do not show any cytotoxicity towards MG63 cells and also have considerably improved osteogenic properties. Overall, Ga doped MBGCs with desired osteogenesis properties compared to Ce doped MBGCs, and Ga doped MBGCs offers encouraging possibilities for the effective repair of bone fractures with implants.
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