Abstract
Objective: Through this work, we aimed to clarify the association between the severity of periodontitis and osteocalcin (OC) gene C298T polymorphismin Indonesian male subjects.Methods: DNA was extracted from blood serum samples of 100 consenting Indonesian men whose periodontitis was classified as mild, moderate,or severe. Polymerase chain reaction and restriction fragment length polymorphism techniques were applied to evaluate the status of OC (C298T)polymorphism using HindIII restriction enzyme and electrophoresis in agarose gel to separate the indicated fragments.Results: Although genotype distribution of the OC C298T polymorphism showed a trend for more frequent occurrence of genotype hh (and allele h)with increasing severity of periodontitis, this trend was not statistically significant in the tested sample population, in whom the HH genotypeappeared to be relatively rare.Conclusion: The results showed no significant association between the severity of periodontitis and OC C298T polymorphism in Indonesian malesubjects.
Highlights
Periodontitis, a complex multifactorial disease, has a high global prevalence, including in Indonesia
The hh genotype appears to be more frequent with increasing severity of periodontitis, with a corresponding decrease in the Hh genotype frequency
The only observed case of genotype HH occurred in a subject with moderate periodontitis
Summary
Periodontitis, a complex multifactorial disease, has a high global prevalence, including in Indonesia. According to the Indonesian national survey on domestic health 2003, dental and oral diseases were ranked first in the 10 most common disease groups affecting individuals; of all dental and oral diseases, periodontal disease was the most common complaint following caries. The survey for the following year (SKRT 2004) indicated a prevalence of 96.6% for periodontal disease [1]. In America, 95% of the >65-year-old population has experienced periodontal attachment loss in at least one side of their mouth. Men have higher levels of periodontal destruction than do women among all age groups [3]
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