Osteoblast and Fibroblast Culture Proliferation on Injectable Calcium Ceramics Polymer Composite

Abstract

Considerable demand for the repair of bone defects cannot be met solely by using biological donor materials. Hence, the use of biocomposites will most likely be increased in reconstructive surgery in future. Metallic implants cannot be used in all cases, because the defects in the skeleton vary greatly, differing from each other in their shape, size, anatomic location, and physiological weight-bearing in the anatomic location. Therefore, more sophisticated orthopaedic materials (e.g. non-metallic fibre-reinforced composites and particulate filler composites) should be available for clinical practice. Our studies have focused on the development of injectable composites of biostable bone cements, i.e. in situ curable resin systems containing impregnated calcium ceramics particles. The properties of the bone cement composites aspire to simulate as closely as possible the mechanical and structural properties of bone. The purpose of this study was to evaluate the in vitro cell proliferation on the experimental injectable biostable polymer modified with calcium ceramics. In the course of proliferation, the cell activity on the calcium ceramics containing biostable polymer composite increased throughout the experiment. As a conclusion, this cell proliferation study indicated that the studied biocomposite has a good potential to promote cell interaction.