Abstract
Osteo-Articular Complications in a Pediatric Sickle Cell Disease Population - Imaging Value
Highlights
Sickle cell disease is part of a group of genetic disorders known as haemoglobinopathies [1,2]
Acute osteomyelitis may be difficult to distinguish from bone infarction and magnetic resonance imaging (MRI) could be an important tool in those cases
This review addresses acute and long-term osteo-articular complications in Sickle cell disease (SCD), with particular emphasis on differentiating infection from infarction, where imaging is playing a crescent role on the acute bone pain diagnosis algorithm
Summary
Sickle cell disease is part of a group of genetic disorders known as haemoglobinopathies [1,2] It results from a mutation in the beta-globin gene on chromosome 11, which replaces glutamic acid in position 6 of beta-globin chain by valine, producing an abnormal haemoglobin S (HbS) molecule [1,2]. Deoxygenation of HbS results in the aggregation of abnormal haemoglobin molecules into long chains that tend to distort the red blood cell membrane into a rigid sickle shape [1,2] (Figure 1). This review addresses acute and long-term osteo-articular complications in SCD, with particular emphasis on differentiating infection from infarction (osteonecrosis), where imaging is playing a crescent role on the acute bone pain diagnosis algorithm
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