Abstract
Solute reflection coefficients, σ i , of rat kidney brush-border membrane vesicles were determined by the comparison of water flows induced by equiosmolal gradients of sucrose and NaCl, KCl or mannitol. The values of 0.53 for σ NaCl and 0.56 for σ KCl when compared with 0.92 for σ mannitol suggested some interactions between salt and water pathways. Altering the membrane proteins with 0.4 mM HgCl 2 decreased the osmotic water permeability of the vesicles by 70 to 80% and brought σ NaCl and σ KCl to a value not different from 1. This argued in favor of water protein pathways in the luminal membrane of kidney proximal cells which are partly accessible to NaCl and KCl.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Biomembranes
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