Abstract
A multi-phase flow strategy, based on oscillatory motion of a bi-phasic slug within a fluorinated ethylene propylene (FEP) tubular reactor, under inert atmosphere, is designed and developed to address mixing and mass transfer limitations associated with continuous slug flow chemistry platforms for studies of bi-phasic catalytic reactions. The technique is exemplified with C-C and C-N Pd catalyzed coupling reactions.
Highlights
Over the past decade, continuous flow technologies have emerged as a powerful tool for the production of pharmaceutical targets or intermediates.[1,2] despite the great advantages of small scale technologies compared to batch systems,[3] the applicability of continuous droplet flow chemistry platforms for bi-phasic chemical reactions is limited
A multi-phase flow strategy, based on oscillatory motion of a bi-phasic slug within a fluorinated ethylene propylene (FEP) tubular reactor, under inert atmosphere, is designed and developed to address mixing and mass transfer limitations associated with continuous slug flow chemistry platforms for studies of bi-phasic catalytic reactions
Slow mass transfer and mixing characteristics combined with residence time limitations, have reduced the utility of droplet-based strategies for studies of bi-phasic chemical reactions
Summary
Continuous flow technologies have emerged as a powerful tool for the production of pharmaceutical targets or intermediates.[1,2] despite the great advantages of small scale technologies compared to batch systems,[3] the applicability of continuous droplet flow chemistry platforms for bi-phasic chemical reactions is limited. A multi-phase flow strategy, based on oscillatory motion of a bi-phasic slug within a fluorinated ethylene propylene (FEP) tubular reactor, under inert atmosphere, is designed and developed to address mixing and mass transfer limitations associated with continuous slug flow chemistry platforms for studies of bi-phasic catalytic reactions.
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