Oscillatory three-phase flow reactor for studies of bi-phasic catalytic reactions.

Milad Abolhasani,Nicholas C. Bruno,Klavs F. Jensen

doi:10.1039/c5cc02051d

Abstract

A multi-phase flow strategy, based on oscillatory motion of a bi-phasic slug within a fluorinated ethylene propylene (FEP) tubular reactor, under inert atmosphere, is designed and developed to address mixing and mass transfer limitations associated with continuous slug flow chemistry platforms for studies of bi-phasic catalytic reactions. The technique is exemplified with C-C and C-N Pd catalyzed coupling reactions.

Highlights

Over the past decade, continuous flow technologies have emerged as a powerful tool for the production of pharmaceutical targets or intermediates.[1,2] despite the great advantages of small scale technologies compared to batch systems,[3] the applicability of continuous droplet flow chemistry platforms for bi-phasic chemical reactions is limited
A multi-phase flow strategy, based on oscillatory motion of a bi-phasic slug within a fluorinated ethylene propylene (FEP) tubular reactor, under inert atmosphere, is designed and developed to address mixing and mass transfer limitations associated with continuous slug flow chemistry platforms for studies of bi-phasic catalytic reactions
Slow mass transfer and mixing characteristics combined with residence time limitations, have reduced the utility of droplet-based strategies for studies of bi-phasic chemical reactions

Summary

Introduction

Continuous flow technologies have emerged as a powerful tool for the production of pharmaceutical targets or intermediates.[1,2] despite the great advantages of small scale technologies compared to batch systems,[3] the applicability of continuous droplet flow chemistry platforms for bi-phasic chemical reactions is limited. A multi-phase flow strategy, based on oscillatory motion of a bi-phasic slug within a fluorinated ethylene propylene (FEP) tubular reactor, under inert atmosphere, is designed and developed to address mixing and mass transfer limitations associated with continuous slug flow chemistry platforms for studies of bi-phasic catalytic reactions.

Results

Conclusion