Abstract
Continuous multiphase flow strategies are commonly employed for high-throughput parameter screening of physical, chemical, and biological processes as well as continuous preparation of a wide range of fine chemicals and micro/nano particles with processing times up to 10 min. The inter-dependency of mixing and residence times, and their direct correlation with reactor length have limited the adaptation of multiphase flow strategies for studies of processes with relatively long processing times (0.5-24 h). In this frontier article, we describe an oscillatory multiphase flow strategy to decouple mixing and residence times and enable investigation of longer timescale experiments than typically feasible with conventional continuous multiphase flow approaches. We review current oscillatory multiphase flow technologies, provide an overview of the advancements of this relatively new strategy in chemistry and biology, and close with a perspective on future opportunities.
Highlights
Oscillatory multiphase flow techniques over the past couple of years have demonstrated the possibility of adaptation of microscale flow technologies for studies of long-term (>30 min) physical, chemical, and biological processes by addressing the residence time limitation associated with continuous multiphase flow strategies
A single microdroplet could be used for kinetic studies of thechemical reaction at a defined temperature, pressure, and concentration
Multiplexed oscillatory multiphase flow platforms could be envisioned for high-throughput parameter screening of gas/ liquid–liquid reactions in a numbered up reactor configuration, operating at different temperatures to surpass conventional batch scale and well-plate based high-throughput screening strategies operated at a constant temperature
Summary
Continuous multiphase flow strategies are commonly employed for high-throughput parameter screening of physical, chemical, and biological processes as well as continuous preparation of a wide range of fine chemicals and micro/nano particles with processing times up to 10 min. The inter-dependency of mixing and residence times, and their direct correlation with reactor length have limited the adaptation of multiphase flow strategies for studies of processes with relatively long processing times (0.5–24 h). We review current oscillatory multiphase flow technologies, provide an overview of the advancements of this relatively new strategy in chemistry and biology, and close with a perspective on future opportunities
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