Abstract
Nonlinear excitations of waves are investigated in a two-dimensional cell network with bidirectional paracrine signaling, both in the longitudinal and transversal directions. The semi-discrete approximation is used to show that the dynamics of the intercellular waves can be reduced to complex Ginzburg–Landau equations, depending on the high- or low-frequency regime. The onset of modulational instability is addressed, where the instability features of the low- and high-frequency modes are compared via the instability growth rate. The -expansion method is employed to find analytically spiral-like wave solutions for the two dynamical regimes. Their response to the effect of paracrine coupling is also addressed.
Published Version
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