OS 33-01 RELATIONSHIPS OF VISCERAL FAT AREA AND INSULIN RESISTANCE INDEX WITH BLOOD PRESSURE STATUS

Abstract

Patients with type 2 diabetes mellitus (DM) or metabolic syndrome have a larger visceral fat area (VFA) and a higher homeostasis model assessment of insulin resistance (HOMA-IR) index; however, the associations of VFA and HOMA-IR with hypertension (HT) remains unclear. We investigated the relationships of blood pressure (BP) status with various metabolic parameters, including VFA, subcutaneous fat area (SFA) and HOMA-IR, in participants in our health checkup program. A total of 3,854 male and 2,545 female Japanese subjects, aged 16–93 years (median: 60 years), who participated in our comprehensive health checkup program between August 2012 and March 2015, were enrolled in this study. Informed consent was obtained from each subject, and subjects who met the predetermined exclusion criteria or were on treatment for DM were excluded from the analyses. We divided participants into 4 groups according to BP status: normotensive (NT), high normal (HN), HT, and HT with medication (HT + Tx). We used computed tomography to measure VFA, SFA and waist circumference (WC) at the umbilical level. Participants aged 50–70 years in the HN, HT, and HT + Tx groups had significantly higher mean VFAs than their counterparts in the NT group (men: n = 2,042, F = 68.7, P 20 g/day) were relevant (P < 0.0001). These results from our comprehensive health checkup program suggest that age, family history of HT, VFA and HOMA-IR are independently related to HT status.