A0435 Visceral fat area, insulin resistance index and alcohol intake were related to blood pressure status in comprehensive health checkup

Abstract

Objectives: Relations of visceral fat with hypertension (HT) have been reported in both Caucasians and in Asians. However, few studies have examined each systolic and diastolic blood pressure (BP) in detail. We investigated the relations of BP status with various metabolic parameters, including visceral fat area (VFA), subcutaneous fat area (SFA), insulin resistance index HOMA-IR and lifestyle habits in participants in our health checkup program. Methods: A total of 3,854 male and 2,545 female subjects, aged 16–93 years (median: 60 years), who participated in our comprehensive health checkup program during 32 months, were enrolled in this study. Informed consent was obtained from each subject, and subjects who met the predetermined exclusion criteria or were on treatment for diabetes mellitus (DM) were excluded from the analyses. We divided participants into 4 groups according to BP status: normotensive (NT), high normal (HN), HT, and HT with medication (HT + Tx). We used low-energy computed tomography to measure VFA, SFA and waist circumference (WC) at the umbilical level. Results: Participants aged 50–70 years in the HN, HT, and HT + Tx groups had significantly higher mean VFAs compared with subjects in the NT group (P < 0.0001 for both gender). In univariate and multivariate analyses, systolic BP was correlated with age, VFA and HOMA-IR, and diastolic BP was correlated with VFA, family history (FH) of HT and alcohol intake (> 20 g/day). Furthermore, multiple logistic regression analyses (including HT + Tx group) with HT as a dependent variable revealed that age, FH of HT, VFA, HOMA-IR and alcohol intake were relevant (P < 0.0001). Conclusion: These results from our comprehensive health checkup program suggest that age, FH of HT, VFA, HOMA-IR and alcohol intake are independently related to HT status.