Abstract
We present a straightforward route for the preparation of orthogonally protected oxadiazole-based building blocks in high yields. Their structures contain a Boc-protected amine and an ester group, thus rendering the compounds amenable to functionalization or integration into larger structures. Thus, we provided access to interesting and innovative building blocks/decorated scaffolds for drug discovery. Keywords: 1, 2, 4-oxadiazole, 1, 3, 4-oxadiazole, building block, privileged structure, scaffold.
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