Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent

Saeed Akbarian

doi:10.11648/j.ajn.20170301.12

Abstract

Design and evaluation of new chemically nano composites towards molecular imaging of malignant tumors is being considered as a kind of medical global research interests. In the current experiment novel nano-composite based on gadolinium ions and anionic linear globular Dendrimer G2 (as biocompatible biodegradable hybrid nanomaterial grafted to folic acid was developed and biophysically assayed. The results showed a very good Magnetic Resonance (MR) relaxivity data on T2 decreasing as well as a very good cellular uptake and tolerance. The complex was found toxic with employing apoptosis as main mechanism of action on cancerous cells respectively. Based on results it could be concluded that such nano-complex may be used as novel theranostic agent in further in vivo practices in near future.

Highlights

In current medicinal practice attractive reverberation imaging (MRI) system has an across the board application in diagnosis [1]
TLC showed that a distinct bond has been added in comparison to the previous sample that confirmed the synthesis
1318 cm-1 peak in FT-IR relates to the terminal G1 citric acid moiety and the new citric acids ester C-O bond that verifies the synthesis of the G2 dendrimer. 1647 cm-1 peak stands for the terminal G2 citric acid moieties

Summary

Introduction

In current medicinal practice attractive reverberation imaging (MRI) system has an across the board application in diagnosis [1]. It is noninvasive and gives high spatial resolution [2]. Among the complexity specialists in clinical practice chelated paramagnetic salts of gadolinium (Gd) and super paramagnetic iron oxide nanoparticles (SPIONPs) are outstanding [1]. SPIONPs need changeless polarization and in this manner conglomeration issue minimizes [2]. Their super paramagnetic nature renders them the ability to be used in low focuses in vivo [4]. As opposed to gadolinium salts, Iron Based nanoparticle act free of the fringe water environment and decrease the powerful transverse unwinding time (T2) of tissues with a superior lethality profile [5, 6]

Methods

Results

Conclusion