Origin and spatiotemporal dynamics of the peroxisomal endomembrane system.

Vladimir I Titorenko,Richard A Rachubinski

doi:10.3389/fphys.2014.00493

Vladimir I Titorenko, Richard A Rachubinski

Open Access

https://doi.org/10.3389/fphys.2014.00493

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Abstract

Origin and spatiotemporal dynamics of the peroxisomal endomembrane system.

Highlights

Peroxisomal endomembrane system cargo protein across the membrane and its release into the peroxisomal matrix, and the recycling of receptor molecules. Ast et al (2013) discuss the molecular mechanisms by which isoforms of proteins known to be peroxisomal can be actively sorted to the cytosol, mitochondrion, nucleus, or plastid
The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria (Islinger et al., 2012; Beach and Titorenko, 2013; Wanders, 2014)
One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum (ER) template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins (Titorenko and Rachubinski, 2009; Hu et al., 2012; Tabak et al., 2013)

Summary

Introduction

Peroxisomal endomembrane system cargo protein across the membrane and its release into the peroxisomal matrix, and the recycling of receptor molecules. Ast et al (2013) discuss the molecular mechanisms by which isoforms of proteins known to be peroxisomal can be actively sorted to the cytosol, mitochondrion, nucleus, or plastid. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity (Titorenko and Rachubinski, 2004; Dixit et al., 2010; Beach et al., 2012).

Results

Conclusion