Abstract
Silver nanoparticles were synthesized using solution combustion method with citric acid as fuel. The prepared silver nanoparticles exhibit fcc crystalline structure with particle size of ~50 nm. The morphology and purity of the silver nanoparticles were also studied by high-resolution transmission electron microscopy (HRTEM) and energy dispersive X-ray analysis (EDX). Surface-enhanced Raman scattering (SERS) spectra of 2,6-dicarbethoxy-3,5-bis(pyridine-3-yl)tetrahydro-1,4-thiazine-1,1-dioxide (DBTD) adsorbed on silver nanoparticles were investigated. Orientation of DBTD on silver nanoparticles has been inferred from normal Raman spectrum (nRs) and SERS spectral feature. The observed spectral feature evidenced that DBTD would adsorb on silver surface with tilted orientation through the lone pair electrons of C–N, C=O, S=O, and pyridine ring. The present investigation has been a model system to deduce the interaction of drugs with DNA.
Highlights
Surface-Enhanced Raman spectroscopy (SERS) is a Raman spectroscopic (RS) technique that provides enhanced Raman signal from Raman-active molecules that have been adsorbed onto certain specially prepared metal surfaces
The symmetry of a molecule can be changed in different ways depending on the orientation in which the molecule is International Journal of Spectroscopy attached to the surface
Using confocal optics a lateral resolution of 1 micron and an axial resolution of 2 micron can be achieved. 600 and 1800 lines/mm gratings were used for dispersive geometry, the charge-coupled device (CCD) camera was used as the detector with the spectral resolution of 1 cm−1
Summary
Surface-Enhanced Raman spectroscopy (SERS) is a Raman spectroscopic (RS) technique that provides enhanced Raman signal from Raman-active molecules that have been adsorbed onto certain specially prepared metal surfaces. Increases in the intensity of Raman signal have been regularly observed in the order of 104–106 and can be as high as 108 and 1014 for some systems [1, 2] The discovery of such an enormous enhancement in the Raman intensity when a molecule is in the vicinity of metal nanoparticles, coupled with the suppression of fluorescence, generated considerable excitement and suggested the possibility that SERS could provide an invaluable tool as a reliable, high-resolution detection technique for extremely minute quantities of target molecules [3]. Thiazines display many important biological activities such as antitussive [10], anesthetic [11], antiradiation [12], anticonvulsant [13], sedative [14], anticoagulant [15], neuroleptic [16], and herbicide antidote [17]. The present investigation has been a model system to deduce the interaction of drugs with DNA
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