Abstract
Two novel organo tin carboxylate complexes (BuSnO)6L6 and Bu3SnOL, where L = a cinnamic acid unit containing polyether chains, were rationally designed for two-photon fluorescent imaging and anticancer purpose. The organotin (IV) complex (BuSnO)6L6 possessed strong one-photon exited fluorescence (1PF) intensity and moderate two-photon absorption cross-section in the near infrared region. Living cell evaluation revealed that (BuSnO)6L6 exhibited good bio-compatibility and outstanding selectivity in the selected tumor cell lines as well as in the normal cells. Furthermore, the anti-tumor activity and mechanism of (BuSnO)6L6 have been investigated systematically. The results indicated that (BuSnO)6L6 could induce apoptotic cell death through a mitochondrial dysfunction, ROS (Reactive oxygen species produced by cell during metabolism) and Cytochrome c elevation pathway. This work provides a novel strategy for rationally designing carboxylate organotin complex with two-photon activity and anti-tumor activity.
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