Abstract
Synthesis, characterization, DNA/BSA binding and cytotoxicity of organometallic binuclear Ru (II) complexes [(p-cym)(Fc-AA)Ru(μ-Im)Ru(Fc-AA)(p-cym)]Cl (C1–C4; where: p-cym = p-cymene MeC6H4Pri, Fc-AA = N-ferrocenyl amino acid conjugates (Fc-tyr1, Fc-phe2, Fc-leu3, Fc-trp4) and Im = Imidazole) have been described. The complexes C1–C4 exhibited strong DNA/BSA binding affinity and cytotoxicity against human cervical cancer HeLa cell line. Their binding with calf thymus CT-DNA and bovine serum albumin BSA have been examined by absorption and emission spectral studies. Intercalative interactions between complexes and CT-DNA have been affirmed by EB displacement studies and DNA viscosity measurements, while interaction with BSA via static quenching was explored by fluorescence titration. The anti-cancer activity of C1–C4 was studied using MTT assay on HeLa cell line and the corresponding IC50 values were calculated. The IC50 value (30.0 μM–120.0 μM) obtained were further compared with the well-known ruthenium complex NAMI-A, currently under phase II clinical trials which has IC50 value 608.5 μM.
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