Abstract
BackgroundEnvironmental factors namely pesticides may contribute to the development of cancer through epigenetic mechanisms. In order to evaluate the impact of organochlorine pesticides (OCPs) on promoter methylation of O6-methylguanine-DNA methyltransferase (MGMT) in thyroid cancer, this research was designed. MethodsIn this study, DNA methylation profile of 61 papillary thyroid carcinoma (PTC) and 70 benign thyroid nodules (BTN) subjects was carried out. In order to measure MGMT gene promoter methylation, methylation-specific PCR (MSP) was used. ResultsHypermethylation of MGMT marker were found in PTC compare with BTN. Also, OCPs increased the odds ratio of methylation of MGMT (OR = 3.66, P = 0.001). Logistic regression analysis showed that OCPs enhance the methylation of MGMT. ConclusionThe results indicated that OCPs lead to PTC development through MGMT gene promoter hypermethylation. Furthermore, MGMT promoter methylation assessment could forecast PTC incidence.
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