Abstract
The structure of spirooxindoles is present in a large number of natural compounds, with relevant and different biological activities. The organic synthesis of these compounds has been a synthetic challenge due to the fusion of two or more cycles with one or more contiguous stereogenic centers. In this review, it has been described, the feasibility of organocatalytic asymmetric synthesis for the achievement of chiral spirooxindoles through two‐ or three‐component reaction in the presence of a chiral organocatalyst producing the compounds with high yield, high diastereoselectivity and with high enantiomeric purity. This review covers literature from 2010 to 2019. The most explored reactions for this purpose have been 1,3‐dipolar cycloaddition, Diels‐Alder and nucleophilic heterocyclic carbenes reactions, where their reaction mechanisms showed in this review are an approach of a possible mechanism.
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