Abstract
A novel protocol for the organocatalytic conversion of arylglyoxals into the corresponding α-hydroxy arylacetic acid methyl esters has been developed. The catalyst consists of a combination of a commercially available cinchona alkaloid derivative and an achiral thiol and leads to enantiomerically enriched products (ee max 83%) under mild reaction conditions. The alkaloid can be easily recovered and reused without loss in activity and selectivity.
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