Abstract
The first asymmetric sulfa-Michael addition of thiols to trans -3,3,3-trifluoropropenyl phenyl sulfone for the construction of a unique stereogenic center bearing a trifluoromethyl group and a sulfur atom has been achieved in high yields and moderate to good enantioselectivities with 1 mol % bifunctional amine–thiourea catalyst. The first asymmetric sulfa-Michael addition of thiols to trans -3,3,3-trifluoropropenyl phenyl sulfone for the construction of a unique stereogenic center bearing a trifluoromethyl group and a sulfur atom has been achieved in high yields and moderate to good enantioselectivities with 1 mol % bifunctional amine–thiourea catalyst.
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