Enantioselective Synthesis of Coumarins Catalyzed by a Bifunctional Amine–Thiourea Catalyst

Abstract

Efficient excess: An efficient and facile enantioselective Michael addition reaction through hydrogen-bonding catalysis for the synthesis of coumarin complexes has been developed (see scheme). A simple bifunctional amine–thiourea small molecule has been discovered to catalyze this process with high yields and high to excellent enantiomeric excesses. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.