Abstract
In this chapter we will summarize several of the experimental approaches we have been taking to examine human histone genes. The structure and organization of human histone genes will be discussed, particularly within the context of the putative relationships of specific regions of the genes to their expression. Approaches to assessing the levels at which control of histone gene expression resides will also be considered. Results will be presented which suggest that: a) Human histone genes are a family of moderately reiterated sequences with variations in the structure, organization, and possibly in the regulation of the various copies. b) At least 15 different, though not necessarily all, human histone genes are coordinately expressed during the S phase of the cell cycle and appear to be temporally and functionally coupled with DNA replication. c) There are both transcriptional and post-transcriptional components to the regulation of those histone genes expressed in conjunction with DNA replication.
Published Version
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