Abstract
Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi). Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was analyzed by molecular orbital and density of state (DOS) using DFT.
Highlights
The use of diverse nanomaterials as antibacterial agents is growing due to their small size, which ensures desirable contact with bacterial cells; in particular, harmless materials that can effectively inhibit bacterial growth is potentially important for preserving packaged food, pharmaceutical and cosmetic products [1]
Inorganic-based NPs are effective at inhibiting bacterial growth, their accumulation in biological tissues or in food materials can cause serious problems as they are non-biodegradable
All the NPs were characterized by UV-visible spectrophotometry, Transmission
Summary
The use of diverse nanomaterials as antibacterial agents is growing due to their small size, which ensures desirable contact with bacterial cells; in particular, harmless materials that can effectively inhibit bacterial growth is potentially important for preserving packaged food, pharmaceutical and cosmetic products [1]. Organic molecules such as ampicillin, amoxicillin, benzylpenicilllin, bleomycin, cefamandole, levofloxacin, clarithromycin, lincomycin and tetracyclines (antibiotics), and amphotericin, griseofulvin, metronidazole (antifungals) have been shown as efficient antibacterial or anti-viral agents The accumulation of these molecules in biological systems is much lower and they are biodegradable. The electronic/optical properties of ONPs are important because their van der Waals intermolecular forces, hydrogen-bonding interactions, and electrostatic attractions are fundamentally different from those of inorganic metals or semiconductors [30]. The changes in their physical and chemical properties increase exponentially with the surface area from NPs to bulk materials [31,32]
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