Abstract
The modulation of single-walled carbon nanotube (SWCNT) photoluminescence has been under investigation for the unique potential to develop biosensors capable of detecting many classes of analytes. Covalent sp3 defects have introduced emissive color centers on SWCNTs, significantly enhancing photoluminescence quantum yield and chemical selectivity/sensitivity to certain analytes. The application of these organic color centers (OCCs) for biomedical applications requires new methods to both conduct covalent chemistry and to concomitantly control the surface chemistry and the resulting biological interactions/biocompatibility via their supramolecular interactions with polymers and other excipients. We will report specific utilities of OCCs for the detection of chemical phenomena where SWCNT photoluminescence is normally relatively insensitive, such as pH changes in the physiologic range of 4.5 - 8. We have developed OCCs to measure endolysosomal pH in live cells and in vivo, as well as other emerging applications. The results support the feasibility of using OCCs as biosensors for disease detection and biomedical research.
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