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https://doi.org/10.1016/j.bmcl.2010.01.107
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Cite Publication Date: Jan 25, 2010 | |
 Citations: 7 |
Affiliation: Pfizer (United States)
Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold binding selectivity against 5HT2b receptor. After medicinal chemistry optimization and SAR studies, orally active proline amides with robust efficacy in a rodent food intake inhibition model were uncovered.
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