ORAL SQUAMOUS CELL CARCINOMA WITH MANDIBULAR BONE INVASION: CASE REPORT

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Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. Bone invasion by OSCC can have different clinical behavior and a variable prognosis. A 58-year-old man was referred to the Dental Specialties Center with complaint of a rapidly developing oral wound. On intraoral examination, leukoplakia associated with ulcerated areas on the lateral tongue and lower right alveolar ridge was observed. Computed tomography revealed a hypodense and infiltrative lesion in the mandibular bone and disruption of the cortical bone. After biopsy, microscopic examination showed malignant epithelial neoplasia composed of islands of neoplastic cells with intense pleomorphism, nuclear hyperchromatism, atypical mitoses, and prominent nucleoli. The final diagnosis of OSCC with mandibular bone invasion was obtained. The patient underwent surgical resection with an adequate tumor margin and neck dissection. Currently, the patient is in follow-up without recurrence. Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. Bone invasion by OSCC can have different clinical behavior and a variable prognosis. A 58-year-old man was referred to the Dental Specialties Center with complaint of a rapidly developing oral wound. On intraoral examination, leukoplakia associated with ulcerated areas on the lateral tongue and lower right alveolar ridge was observed. Computed tomography revealed a hypodense and infiltrative lesion in the mandibular bone and disruption of the cortical bone. After biopsy, microscopic examination showed malignant epithelial neoplasia composed of islands of neoplastic cells with intense pleomorphism, nuclear hyperchromatism, atypical mitoses, and prominent nucleoli. The final diagnosis of OSCC with mandibular bone invasion was obtained. The patient underwent surgical resection with an adequate tumor margin and neck dissection. Currently, the patient is in follow-up without recurrence.