Abstract
Sudden Sensory Neural Hearing Loss (SSNHL) is a serious medical condition and requires prompt medical attention. The study was done to estimate the effect of different protocols of oral Prednisolone plus high dose vitamin B-complex and vitamin BI, 132. Be in patients with unilateral SSNHL who have failed to respond to treatment. A retrospective study was done from January 2015 to January 2018 at the outdoor patient department of Holy Family Red Crescent Medical College Hospital, Dhaka among 75 randomly selected patients with a mean age of 46.32 years (range 25-69 years). with the preselected criteria. Each of the patient received one of the four standard oral Prednisolone dosing protocols along with high dose of vitamin B-complex and BI, 132, Be orally 20mg four times for a total dose of 80mg daily for one week, Group A, n=18; orally 20 mg three times, for a total dose of 60mg daily for one week Group B, n=18; orally 20mg two times for a total dose of 40mg daily for one week Group C, n=18; orally 10mg three times for a total dose of 30mg daily for one week. Group a n=18. All the doses were then tapered for next 5 days. Patient characteristics and pharmacological effects were compared among the 4 groups. The mean age, average duration of symptoms from onset to treatment, and degree of hearing loss were analyzed by means oft-test Treatment effects were analyzed by means of Chi-square test. P<0.05 was considered significant. Improvement of hearing was assessed by pure tone audiogram. The total effective rate was 88.89% 83.33%, 77.78% 66.67% for each treatment protocol, respectively, with no significant statistical difference between them (p00.05). The results suggest that a total dose of 80 mg is the most appropriate protocol. Prednisolone significantly improves the prognosis of SSNHL. Further multicenter studies are needed to determine the more standard treatment protocol.
Published Version
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