Oral pigmentations in Laugier-Hunziker syndrome: a case report and review of diagnostic criteria

Luiz Arthur B Silva,Ana Miryam C Medeiros,Éricka Janine D Silveira,Leão P Pinto,Patrícia T Oliveira,Rodrigo P Mafra

doi:10.5935/1676-2444.20180011

Luiz Arthur B Silva, Ana Miryam C Medeiros + Show 4 more

Open Access

https://doi.org/10.5935/1676-2444.20180011

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Abstract

ABSTRACT Laugier-Hunziker syndrome (LHS) is a rare mucocutaneous disorder, of unknown etiology, characterized by multiple hyperpigmented macules, dispersed mostly on the oral mucosa, occasionally associated with longitudinal ridging of the nails. The diagnosis requires exclusion of other conditions, such as Addison's disease and Peutz-Jeghers syndrome. We report a case of a 34-year-old male patient, presenting with hyperpigmented macules on the lips, buccal mucosa and palate, as well as mild dark striations on toenails. After careful clinical and laboratorial investigations, the diagnosis of LHS was established. Given the lack of aesthetic complaints and symptoms, no treatment was necessary.

Highlights

The Laugier-Hunziker syndrome (LHS) is a rare acquired mucocutaneous disorder of undetermined etiology[1]
LHS is a rare condition of unknown pathogenesis, with a limited number of reported cases since its first description in 1970(6, 7)
We report a case of LHS in a male patient, our review demonstrated that this condition is more common in women (72%), with a female/ male incidence ratio of 2.75:1

Summary

Case report

J Bras Patol Med Lab. 2018 Feb; 54(1): 52-56. Oral pigmentations in Laugier-Hunziker syndrome: a case report and review of diagnostic criteria. Pigmentações orais na síndrome de Laugier-Hunziker: relato de caso e revisão dos critérios de diagnóstico. Laugier-Hunziker syndrome (LHS) is a rare mucocutaneous disorder, of unknown etiology, characterized by multiple hyperpigmented macules, dispersed mostly on the oral mucosa, occasionally associated with longitudinal ridging of the nails. The diagnosis requires exclusion of other conditions, such as Addison’s disease and Peutz-Jeghers syndrome. We report a case of a 34-year-old male patient, presenting with hyperpigmented macules on the lips, buccal mucosa and palate, as well as mild dark striations on toenails. After careful clinical and laboratorial investigations, the diagnosis of LHS was established.

Introduction

Discussion

Other manifestations

Findings

Longitudinal melanonychia in nails