Oral Microbiota as a Diagnostic Biomarker of Digestive Cancer: A Systematic Review.

Abstract

This article aimed to review the association of oral microbiota with digestive cancer (DC). Oral microbiota is one of the most complex ecosystems in our body. The mouth, from which the digestive system starts, may be a source of an abundant taxonomic group of microbiotas that travel to the digestive system followed by growth, reproduction, and settlement, forming a complex microecological environment causing systemic and gastrointestinal (GI) disease. A total of 14 articles were chosen for review. Most studies were case-control. Both positive and negative associations were seen between oral microbiome and DC. Digestive cancer may be associated with distinctive oral microbial character. The present systematic review enlightens the risk of digestive carcinoma with oral microbiota that may act as a biomarker for early diagnosis of DC in a more comfortable, acceptable, and noninvasive way. How to cite this article: Ikbal SKA, Yadav SK, Mehrotra R, et al. Oral Microbiota as a Diagnostic Biomarker of Digestive Cancer: A Systematic Review. J Contemp Dent Pract 2023;24(11):902-911.